ID   OPSD_SHEEP     STANDARD;      PRT;   348 AA.
AC   P02700;
DT   21-JUL-1986 (Rel. 01, Created)
DT   01-FEB-1991 (Rel. 17, Last sequence update)
DT   15-JUL-1999 (Rel. 38, Last annotation update)
DE   RHODOPSIN.
GN   RHO.
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea;
OC   Bovidae; Caprinae; Ovis.
RN   [1]
RP   SEQUENCE.
RA   Pappin D.J.C., Elipoulos E., Brett M., Findlay J.B.C.;
RT   "A structural model for ovine rhodopsin.";
RL   Int. J. Biol. Macromol. 6:73-76(1984).
RN   [2]
RP   SEQUENCE OF 1-111 AND 144-239.
RX   MEDLINE=83282605; PubMed=6224479;
RA   Brett M., Findlay J.B.C.;
RT   "Isolation and characterization of the CNBr peptides from the
RT   proteolytically derived N-terminal fragment of ovine opsin.";
RL   Biochem. J. 211:661-670(1983).
RN   [3]
RP   SEQUENCE OF 240-348.
RX   MEDLINE=82013638; PubMed=7278988;
RA   Findlay J.B.C., Brett M., Pappin D.J.C.;
RT   "Primary structure of C-terminal functional sites in ovine
RT   rhodopsin.";
RL   Nature 293:314-316(1981).
RN   [4]
RP   RETINAL BINDING SITE.
RX   MEDLINE=84178280; PubMed=6370231;
RA   Pappin D.J.C., Findlay J.B.C.;
RT   "Sequence variability in the retinal-attachment domain of mammalian
RT   rhodopsins.";
RL   Biochem. J. 217:605-613(1984).
CC   -!- FUNCTION: VISUAL PIGMENTS ARE THE LIGHT-ABSORBING MOLECULES THAT
CC       MEDIATE VISION. THEY CONSIST OF AN APOPROTEIN, OPSIN, COVALENTLY
CC       LINKED TO CIS-RETINAL.
CC   -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN.
CC   -!- TISSUE SPECIFICITY: ROD SHAPED PHOTORECEPTOR CELLS WHICH MEDIATES
CC       VISION IN DIM LIGHT.
CC   -!- PTM: SOME OR ALL OF THE CARBOXYL-TERMINAL SER OR THR RESIDUES MAY
CC       BE PHOSPHORYLATED.
CC   -!- MISCELLANEOUS: THIS RHODOPSIN HAS AN ABSORPTION MAXIMA AT 495 NM.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
CC       OPSIN SUBFAMILY.
DR   PIR; A30407; OOSH.
DR   GCRDB; GCR_0194; -.
DR   INTERPRO; IPR000276; -.
DR   INTERPRO; IPR000732; -.
DR   INTERPRO; IPR001760; -.
DR   PFAM; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00238; OPSIN.
DR   PRINTS; PR00579; RHODOPSIN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   PROSITE; PS00238; OPSIN; 1.
KW   Photoreceptor; Retinal protein; Transmembrane; Glycoprotein; Vision;
KW   Phosphorylation; Lipoprotein; Palmitate; G-protein coupled receptor.
FT   DOMAIN        1     36       EXTRACELLULAR.
FT   TRANSMEM     37     61       1 (POTENTIAL).
FT   DOMAIN       62     73       CYTOPLASMIC.
FT   TRANSMEM     74     98       2 (POTENTIAL).
FT   DOMAIN       99    113       EXTRACELLULAR.
FT   TRANSMEM    114    133       3 (POTENTIAL).
FT   DOMAIN      134    152       CYTOPLASMIC.
FT   TRANSMEM    153    176       4 (POTENTIAL).
FT   DOMAIN      177    202       EXTRACELLULAR.
FT   TRANSMEM    203    230       5 (POTENTIAL).
FT   DOMAIN      231    252       CYTOPLASMIC.
FT   TRANSMEM    253    276       6 (POTENTIAL).
FT   DOMAIN      277    284       EXTRACELLULAR.
FT   TRANSMEM    285    309       7 (POTENTIAL).
FT   DOMAIN      310    348       CYTOPLASMIC.
FT   CARBOHYD      2      2       N-LINKED (GLCNAC...) (BY SIMILARITY).
FT   CARBOHYD     15     15       N-LINKED (GLCNAC...) (BY SIMILARITY).
FT   BINDING     296    296       RETINAL CHROMOPHORE.
FT   LIPID       322    322       PALMITATE (BY SIMILARITY).
FT   LIPID       323    323       PALMITATE (BY SIMILARITY).
FT   DISULFID    110    187       BY SIMILARITY.
FT   MOD_RES     343    343       PHOSPHORYLATION (BY RK) (BY SIMILARITY).
SQ   SEQUENCE   348 AA;  38891 MW;  AAFD6F0D6A8BAEE5 CRC64;
     MNGTEGPNFY VPFSNKTGVV RSPFEAPQYY LAEPWQFSML AAYMFLLIVL GFPINFLTLY
     VTVQHKKLRT PLNYILLNLA VADLFMVFGG FTTTLYTSLH GYFVFGPTGC NLEGFFATLG
     GEIALWSLVV LAIERYVVVC KPMSNFRFGE NHAIMGVAFT WVMALACAAP PLVGWSRYIP
     QGMQCSCGAL YFTLKPEINN ESFVIYMFVV HFSIPLIVIF FCYGQLVFTV KEAAAQQQES
     ATTQKAEKEV TRMVIIMVIA FLICWLPYAG VAFYIFTHQG SDFGPIFMTI PAFFAKSSSV
     YNPVIYIMMN KQFRNCMLTT LCCGKNPLGD DEASTTVSKT ETSQVAPA
//